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Extracellular glucose levels in cultures of undifferentiated mouse trophoblast stem cells affect gene expression during subsequent differentiation with replicable cell line-dependent variation

Mouse trophoblast stem cells (TSCs) have been established and maintained using hyperglycemic conditions (11 mM glucose) for no apparent good reason. Because glucose metabolites are used as resources for cellular energy production, biosynthesis, and epigenetic modifications, differences in extracellu...

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Detalles Bibliográficos
Autores principales: NISHITANI, Kenta, HAYAKAWA, Koji, TANAKA, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379769/
https://www.ncbi.nlm.nih.gov/pubmed/30318498
http://dx.doi.org/10.1262/jrd.2018-083