Thermostability and excision activity of polymorphic forms of hOGG1

OBJECTIVES: Reactive oxygen species (ROS) oxidize guanine residues in DNA to form 7,8-dihydro-oxo-2′-deoxyguanosine (8oxoG) lesions in the genome. Human 8-oxoguanine glycosylase-1 (hOGG1) recognizes and excises this highly mutagenic species when it is base-paired opposite a cytosine. We sought to ch...

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Detalles Bibliográficos
Autores principales: Mouzakis, Kathryn D., Wu, Tiffany, Haushalter, Karl A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379936/
https://www.ncbi.nlm.nih.gov/pubmed/30777129
http://dx.doi.org/10.1186/s13104-019-4111-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379936/
https://www.ncbi.nlm.nih.gov/pubmed/30777129
http://dx.doi.org/10.1186/s13104-019-4111-9

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