Engineering of leucine-responsive regulatory protein improves spiramycin and bitespiramycin biosynthesis

BACKGROUND: Bitespiramycin (BT) is produced by recombinant spiramycin (SP) producing strain Streptomyces spiramyceticus harboring a heterologous 4″-O-isovaleryltransferase gene (ist). Exogenous l-Leucine (l-Leu) could improve the production of BT. The orf2 gene found from the genomic sequence of S....

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Detalles Bibliográficos
Autores principales: Lu, Zhili, Zhang, Xiaoting, Dai, Jianlu, Wang, Yiguang, He, Weiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379999/
https://www.ncbi.nlm.nih.gov/pubmed/30782164
http://dx.doi.org/10.1186/s12934-019-1086-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379999/
https://www.ncbi.nlm.nih.gov/pubmed/30782164
http://dx.doi.org/10.1186/s12934-019-1086-0

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