MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

BACKGROUND: TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists are attractive anti-tumor agents because of their capability to induce apoptosis in cancer cells by activating death receptors (DR) 4 and 5 with little toxicity against normal cells. Despite an attractive mechanism of action...

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Detalles Bibliográficos
Autores principales: Greer, Yoshimi Endo, Gilbert, Samuel F., Gril, Brunilde, Narwal, Rajesh, Peacock Brooks, Danielle L., Tice, David A., Steeg, Patricia S., Lipkowitz, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380056/
https://www.ncbi.nlm.nih.gov/pubmed/30777098
http://dx.doi.org/10.1186/s13058-019-1116-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380056/
https://www.ncbi.nlm.nih.gov/pubmed/30777098
http://dx.doi.org/10.1186/s13058-019-1116-1

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