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Mutagenesis of Snu114 domain IV identifies a developmental role in meiotic splicing
Snu114, a component of the U5 snRNP, plays a key role in activation of the spliceosome. It controls the action of Brr2, an RNA-stimulated ATPase/RNA helicase that disrupts U4/U6 snRNA base-pairing prior to formation of the spliceosome’s catalytic centre. Snu114 has a highly conserved domain structur...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380292/ https://www.ncbi.nlm.nih.gov/pubmed/30672374 http://dx.doi.org/10.1080/15476286.2018.1561145 |