Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases

Plant homeodomain (PHD) containing proteins are important epigenetic regulators and are of interest as potential drug targets. Inspired by the amiodarone derivatives reported to inhibit the PHD finger 3 of KDM5A (KDM5A(PHD3)), a set of compounds were synthesised. Amiodarone and its derivatives were...

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Detalles Bibliográficos
Autores principales: Bhushan, Bhaskar, Erdmann, Alexandre, Zhang, Yijia, Belle, Roman, Johannson, Catrine, Oppermann, Udo, Hopkinson, Richard J., Schofield, Christopher J., Kawamura, Akane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380468/
https://www.ncbi.nlm.nih.gov/pubmed/29764755
http://dx.doi.org/10.1016/j.bmc.2018.03.030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380468/
https://www.ncbi.nlm.nih.gov/pubmed/29764755
http://dx.doi.org/10.1016/j.bmc.2018.03.030

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