Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor

Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and replication of HBV. We developed an assay system for...

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Detalles Bibliográficos
Autores principales: Takeuchi, Fumihiko, Ikeda, Sotaro, Tsukamoto, Yuta, Iwasawa, Yoshikazu, Qihao, Chen, Otakaki, Yukie, Ryota, Ouda, Yao, Wan-Ling, Narita, Ryo, Makoto, Hijikata, Watashi, Koichi, Wakita, Takaji, Takeuchi, Koh, Chayama, Kazuaki, Kogure, Amane, Kato, Hiroki, Fujita, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380541/
https://www.ncbi.nlm.nih.gov/pubmed/30779774
http://dx.doi.org/10.1371/journal.pone.0212233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380541/
https://www.ncbi.nlm.nih.gov/pubmed/30779774
http://dx.doi.org/10.1371/journal.pone.0212233

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