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TLR4 signaling improves PD-1 blockade therapy during chronic viral infection

CD8 T cells are necessary for the elimination of intracellular pathogens, but during chronic viral infections, CD8 T cells become exhausted and unable to control the persistent infection. Programmed cell death-1 (PD-1) blockade therapies have been shown to improve CD8 T cell responses during chronic...

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Detalles Bibliográficos
Autores principales: Wang, Yidan, Chung, Young Rock, Eitzinger, Simon, Palacio, Nicole, Gregory, Shana, Bhattacharyya, Mitra, Penaloza-MacMaster, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380600/
https://www.ncbi.nlm.nih.gov/pubmed/30726291
http://dx.doi.org/10.1371/journal.ppat.1007583