Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated ‘don’t eat me signal’.

Macrophages enforce anti-tumor immunity by engulfing and killing tumor cells. Although these functions are determined by a balance of stimulatory and inhibitory signals, the role of macrophage metabolism is unknown. Here, we study the capacity of macrophages to circumvent inhibitory activity mediate...

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Detalles Bibliográficos
Autores principales: Liu, Mingen, O’Connor, Roddy S., Trefely, Sophie, Graham, Kathleen, Snyder, Nathaniel W., Beatty, Gregory L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380920/
https://www.ncbi.nlm.nih.gov/pubmed/30664738
http://dx.doi.org/10.1038/s41590-018-0292-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380920/
https://www.ncbi.nlm.nih.gov/pubmed/30664738
http://dx.doi.org/10.1038/s41590-018-0292-y

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