Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

The current influenza vaccine has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here, we design a vaccine utilizing the hypervariable...

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Detalles Bibliográficos
Autores principales: Kanekiyo, Masaru, Joyce, M. Gordon, Gillespie, Rebecca A., Gallagher, John R., Andrews, Sarah F., Yassine, Hadi M., Wheatley, Adam K., Fisher, Brian E., Ambrozak, David R., Creanga, Adrian, Leung, Kwanyee, Yang, Eun Sung, Boyoglu-Barnum, Seyhan, Georgiev, Ivelin S., Tsybovsky, Yaroslav, Prabhakaran, Madhu S., Andersen, Hanne, Kong, Wing-Pui, Baxa, Ulrich, Zephir, Kathryn L., Ledgerwood, Julie E., Koup, Richard A., Kwong, Peter D., Harris, Audray K., McDermott, Adrian B., Mascola, John R., Graham, Barney S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380945/
https://www.ncbi.nlm.nih.gov/pubmed/30742080
http://dx.doi.org/10.1038/s41590-018-0305-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380945/
https://www.ncbi.nlm.nih.gov/pubmed/30742080
http://dx.doi.org/10.1038/s41590-018-0305-x

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