A negative feedback loop between XBP1 and Fbw7 regulates cancer development

In cancer, activation of X-box binding protein (XBP1) has a critical role in tumorigenesis and cancer progression. Transcriptional regulatory mechanism of XBP1 in cancer development has been well known, however, regulation of ubiquitination and degradation of XBP1 has not been elucidated yet. Here w...

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Detalles Bibliográficos
Autores principales: Chae, Unbin, Lee, Heejin, Kim, Bokyung, Jung, Haiyoung, Kim, Byeong Mo, Lee, Ann- Hwee, Lee, Dong-Seok, Min, Sang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381103/
https://www.ncbi.nlm.nih.gov/pubmed/30783083
http://dx.doi.org/10.1038/s41389-019-0124-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381103/
https://www.ncbi.nlm.nih.gov/pubmed/30783083
http://dx.doi.org/10.1038/s41389-019-0124-4

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