Kindlin-2 links mechano-environment to proline synthesis and tumor growth

Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. Extracellular matrix (ECM) stiffening promotes kindlin-2 translocatio...

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Detalles Bibliográficos
Autores principales: Guo, Ling, Cui, Chunhong, Zhang, Kuo, Wang, Jiaxin, Wang, Yilin, Lu, Yixuan, Chen, Ka, Yuan, Jifan, Xiao, Guozhi, Tang, Bin, Sun, Ying, Wu, Chuanyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381112/
https://www.ncbi.nlm.nih.gov/pubmed/30783087
http://dx.doi.org/10.1038/s41467-019-08772-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381112/
https://www.ncbi.nlm.nih.gov/pubmed/30783087
http://dx.doi.org/10.1038/s41467-019-08772-3

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