Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and has no disease-modifying treatment yet. The hallmarks of AD are two amyloidogenic proteins: tau and amyloid β (Aβ). Tau undergoes several posttranslational modifications, including N-glycosylation. Tau was reported to be N-gl...

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Detalles Bibliográficos
Autores principales: Losev, Yelena, Paul, Ashim, Frenkel-Pinter, Moran, Abu-Hussein, Malak, Khalaila, Isam, Gazit, Ehud, Segal, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381127/
https://www.ncbi.nlm.nih.gov/pubmed/30783169
http://dx.doi.org/10.1038/s41598-019-39218-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381127/
https://www.ncbi.nlm.nih.gov/pubmed/30783169
http://dx.doi.org/10.1038/s41598-019-39218-x

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