An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial–mesenchymal transition (EMT) process. Currently, it remains poorly understood how EMT prog...

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Detalles Bibliográficos
Autores principales: Li, Ningning, Babaei-Jadidi, Roya, Lorenzi, Federica, Spencer-Dene, Bradley, Clarke, Philip, Domingo, Enric, Tulchinsky, Eugene, Vries, Robert G. J., Kerr, David, Pan, Yihang, He, Yulong, Bates, David O., Tomlinson, Ian, Clevers, Hans, Nateri, Abdolrahman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381143/
https://www.ncbi.nlm.nih.gov/pubmed/30783098
http://dx.doi.org/10.1038/s41389-019-0125-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381143/
https://www.ncbi.nlm.nih.gov/pubmed/30783098
http://dx.doi.org/10.1038/s41389-019-0125-3

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