Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3-Hydroxymorphinan

The neuroprotective agent 3-hydroxymorphinan (3-HM) is a well-documented and highly safe therapeutic intervention for the inflammatory-related effects of Parkinson’s disease (PD). However, the bioavailability of 3-HM is very low due to the rapid first-pass metabolism of the phenolic moiety. In the p...

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Detalles Bibliográficos
Autores principales: Li, Ziqiang, Bao, Xiuqi, Bai, Xiaoguang, Zhang, Guoning, Wang, Juxian, Zhu, Mei, Wang, Yue, Shang, Junmei, Sheng, Chanjuan, Zhang, Dan, Wang, Yucheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381151/
https://www.ncbi.nlm.nih.gov/pubmed/30783196
http://dx.doi.org/10.1038/s41598-019-38911-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381151/
https://www.ncbi.nlm.nih.gov/pubmed/30783196
http://dx.doi.org/10.1038/s41598-019-38911-1

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