Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok (−/−) zebrafish

Deoxyguanosine kinase (dGK) is an essential rate-limiting component of the mitochondrial purine nucleotide salvage pathway, encoded by the nuclear gene encoding deoxyguanosine kinase (DGUOK). Mutations in DGUOK lead to mitochondrial DNA (mtDNA) depletion typically in the liver and brain, causing a h...

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Detalles Bibliográficos
Autores principales: Munro, Benjamin, Horvath, Rita, Müller, Juliane S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381312/
https://www.ncbi.nlm.nih.gov/pubmed/30428046
http://dx.doi.org/10.1093/hmg/ddy389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381312/
https://www.ncbi.nlm.nih.gov/pubmed/30428046
http://dx.doi.org/10.1093/hmg/ddy389

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