Cargando…

Glycine Protects against Hypoxic-Ischemic Brain Injury by Regulating Mitochondria-Mediated Autophagy via the AMPK Pathway

Hypoxic-ischemic encephalopathy (HIE) is detrimental to newborns and is associated with high mortality and poor prognosis. Thus, the primary aim of the present study was to determine whether glycine could (1) attenuate HIE injury in rats and hypoxic stress in PC12 cells and (2) downregulate mitochon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Chen-chen, Zhu, Jiang-hu, Ye, Li-xia, Dai, Yuan-yuan, Fang, Ming-chu, Hu, Ying-ying, Pan, Shu-lin, Chen, Si, Li, Pei-jun, Fu, Xiao-qin, Lin, Zhen-lang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381570/ https://www.ncbi.nlm.nih.gov/pubmed/30881590 http://dx.doi.org/10.1155/2019/4248529

Ejemplares similares

Somatic autophagy of axonal mitochondria in ischemic neurons
por: Zheng, Yanrong, et al.
Publicado: (2019)

Role of Mitochondria in Neonatal Hypoxic-Ischemic Brain Injury
por: Lu, Yujiao, et al.
Publicado: (2015)

Chlorogenic acid alleviates hypoxic-ischemic brain injury in neonatal mice
por: Li, Lu-Yao, et al.
Publicado: (2022)

Neferine Protects against Hypoxic-Ischemic Brain Damage in Neonatal Rats by Suppressing NLRP3-Mediated Inflammasome Activation
por: Zhu, Jin-jin, et al.
Publicado: (2021)

Role of AMPK in autophagy
por: Wang, Shengyuan, et al.
Publicado: (2022)

MiR-127-3p targeting CISD1 regulates autophagy in hypoxic–ischemic cortex
por: Zhang, Zi-Bin, et al.
Publicado: (2021)

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy
por: Yang, Ming, et al.
Publicado: (2020)

Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy
por: Xue, Hang, et al.
Publicado: (2019)

Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway
por: Chen, Zhong-Jun, et al.
Publicado: (2020)

Diverse roles of mitochondria in ischemic stroke
por: Yang, Jenq-Lin, et al.
Publicado: (2018)

Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway in hyperplastic prostate
por: Li, Yan, et al.
Publicado: (2023)

Hypoxic-Ischemic Injury in the Developing Brain: The Role of Reactive Oxygen Species Originating in Mitochondria
por: Ten, Vadim S., et al.
Publicado: (2012)

Mitochondria in hypoxic pulmonary hypertension, roles and the potential targets
por: Geng, Yumei, et al.
Publicado: (2023)

Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury
por: Ma, Si-Min, et al.
Publicado: (2015)

Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
por: Geng, Xue, et al.
Publicado: (2021)

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
por: Liu, Rui, et al.
Publicado: (2021)

Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities
por: She, Hong-Qing, et al.
Publicado: (2023)

AMPK and the Challenge of Treating Hypoxic Pulmonary Hypertension
por: Flores, Karen, et al.
Publicado: (2022)

AMPK blunts chronic heart failure by inhibiting autophagy
por: Li, Yanhui, et al.
Publicado: (2018)

Treatment With Liraglutide Exerts Neuroprotection After Hypoxic–Ischemic Brain Injury in Neonatal Rats via the PI3K/AKT/GSK3β Pathway
por: Zeng, Shan-shan, et al.
Publicado: (2020)

A mitochondrial EglN1‐AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress
por: Jiang, Weiwei, et al.
Publicado: (2023)

Hesperetin Induces Autophagy and Delayed Apoptosis by Modulating the AMPK/Akt/mTOR Pathway in Human Leukemia Cells In Vitro
por: Lin, Ching-Yeh, et al.
Publicado: (2023)

Histamine H(2) receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury
por: Jiang, Lei, et al.
Publicado: (2020)

Eliciting α7‐nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling
por: Lin, Zhong‐Hao, et al.
Publicado: (2019)

Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy
por: Yang, Lin, et al.
Publicado: (2016)

Oxygen Tension Variation in Ischemic Gastrocnemius Muscle, Marrow, and different Hypoxic Conditions In Vitro
por: Huang, Ying, et al.
Publicado: (2014)

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury
por: Silachev, Denis N., et al.
Publicado: (2018)

Emodin prevents hypoxic-ischemic neuronal injury: Involvement of the activin A pathway☆
por: Guo, Hongliang, et al.
Publicado: (2013)

Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK
por: Wu, Yue, et al.
Publicado: (2021)

Myocardial Ischemic Postconditioning Promotes Autophagy against Ischemia Reperfusion Injury via the Activation of the nNOS/AMPK/mTOR Pathway
por: Hao, Maojuan, et al.
Publicado: (2017)

DIAPH1-MFN2 interaction regulates mitochondria-SR/ER contact and modulates ischemic/hypoxic stress
por: Yepuri, Gautham, et al.
Publicado: (2023)

Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats
por: Jiang, Li-Jun, et al.
Publicado: (2020)

Preterm Hypoxic–Ischemic Encephalopathy
por: Gopagondanahalli, Krishna Revanna, et al.
Publicado: (2016)

Resveratrol and Angiogenin-2 Combined With PEGDA/TCS Hydrogel for the Targeted Therapy of Hypoxic Bone Defects via Activation of the Autophagy Pathway
por: Fan, Dehui, et al.
Publicado: (2021)

Engineered inhaled nanocatalytic therapy for ischemic cerebrovascular disease by inducing autophagy of abnormal mitochondria
por: Wang, Deping, et al.
Publicado: (2023)

Scutellarin ameliorates neonatal hypoxic-ischemic encephalopathy associated with GAP43-dependent signaling pathway
por: Niu, Rui-Ze, et al.
Publicado: (2021)

Immunomodulatory Mechanism and Potential Therapies for Perinatal Hypoxic-Ischemic Brain Damage
por: Min, Ying-Jun, et al.
Publicado: (2020)

NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic-ischemic injury
por: LAI, QINGWEI, et al.
Publicado: (2016)

Apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondria pathway
por: Hsu, Man-Chen, et al.
Publicado: (2021)

Role of Sirtuin-1 in Neonatal Hypoxic-Ischemic Encephalopathy and Its Underlying Mechanism
por: Zhang, Zhen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_21mep2r6vsvvrbgsivcamcmhe8