Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II

Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function. The mitochondrial lysine deacetylase Sirtuin 3 (Sirt3) reverses this modification with benefits reported in diabetes, obesity, and agin...

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Detalles Bibliográficos
Autores principales: James, Andrew M., Hoogewijs, Kurt, Logan, Angela, Hall, Andrew R., Ding, Shujing, Fearnley, Ian M., Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381604/
https://www.ncbi.nlm.nih.gov/pubmed/28249157
http://dx.doi.org/10.1016/j.celrep.2017.02.018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381604/
https://www.ncbi.nlm.nih.gov/pubmed/28249157
http://dx.doi.org/10.1016/j.celrep.2017.02.018

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