A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway

BACKGROUND: Targeting the c-Met signaling pathway has become a therapeutic strategy in multiple types of cancer. We unveiled a novel c-Met regulating mechanism that could be applied as a modality for oral squamous cell carcinoma (OSCC) therapy. METHODS: Upregulation of keratin 16 (KRT16) was found b...

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Detalles Bibliográficos
Autores principales: Huang, Wei-Chieh, Jang, Te-Hsuan, Tung, Shiao-Lin, Yen, Tzu-Chen, Chan, Shih-Hsuan, Wang, Lu-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381632/
https://www.ncbi.nlm.nih.gov/pubmed/30782177
http://dx.doi.org/10.1186/s13046-019-1091-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381632/
https://www.ncbi.nlm.nih.gov/pubmed/30782177
http://dx.doi.org/10.1186/s13046-019-1091-5

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