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1,25(OH)(2)D(3) deficiency-induced gut microbial dysbiosis degrades the colonic mucus barrier in Cyp27b1 knockout mouse model

BACKGROUND: The relationship between disturbances of the gut microbiota and 1,25(OH)(2)D(3) deficiency has been established both in humans and animal models with a vitamin D poor diet or a lack of sun exposure. Our prior study has demonstrated that Cyp27b1(−/−) (Cyp27b1 knockout) mice that could not...

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Detalles Bibliográficos
Autores principales: Zhu, Wenjing, Yan, Jiayao, Zhi, Chunchun, Zhou, Qianwen, Yuan, Xiaoqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381729/
https://www.ncbi.nlm.nih.gov/pubmed/30828386
http://dx.doi.org/10.1186/s13099-019-0291-z