Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer

Targeted cancer therapeutics select for drug-resistant rescue subclones (RSCs), which typically carry rescue mutations that restore oncogenic signaling. Whereas mutations underlying antibiotic resistance frequently burden drug-naive microbes with a fitness cost, it remains unknown whether and how re...

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Detalles Bibliográficos
Autores principales: Keller, Ross R., Gunther, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382077/
https://www.ncbi.nlm.nih.gov/pubmed/30673612
http://dx.doi.org/10.1016/j.celrep.2018.12.096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382077/
https://www.ncbi.nlm.nih.gov/pubmed/30673612
http://dx.doi.org/10.1016/j.celrep.2018.12.096

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