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Evolution of Relapse-Proficient Subclones Constrained by Collateral Sensitivity to Oncogene Overdose in Wnt-Driven Mammary Cancer
Targeted cancer therapeutics select for drug-resistant rescue subclones (RSCs), which typically carry rescue mutations that restore oncogenic signaling. Whereas mutations underlying antibiotic resistance frequently burden drug-naive microbes with a fitness cost, it remains unknown whether and how re...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382077/ https://www.ncbi.nlm.nih.gov/pubmed/30673612 http://dx.doi.org/10.1016/j.celrep.2018.12.096 |