Preparation of Recombinant Alphaviruses for Functional Studies of ADP-Ribosylation

Recently we characterized the mono(ADP-ribosyl) hydrolase (MAR hydrolase) activity of the macrodomain of nonstructural protein 3 (nsP3(MD)) of chikungunya virus. Using recombinant viruses with targeted mutations in the macrodomain, we demonstrated that hydrolase function is important for viral repli...

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Detalles Bibliográficos
Autores principales: Abraham, Rachy, McPherson, Robert Lyle, Sreekumar, Easwaran, Leung, Anthony K. L., Griffin, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382469/
https://www.ncbi.nlm.nih.gov/pubmed/30097877
http://dx.doi.org/10.1007/978-1-4939-8588-3_21