Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes

Chemically modified mRNA is an efficient, biocompatible modality for therapeutic protein expression. We report a first-time-in-human study of this modality, aiming to evaluate safety and potential therapeutic effects. Men with type 2 diabetes mellitus (T2DM) received intradermal injections of modifi...

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Detalles Bibliográficos
Autores principales: Gan, Li-Ming, Lagerström-Fermér, Maria, Carlsson, Leif G., Arfvidsson, Cecilia, Egnell, Ann-Charlotte, Rudvik, Anna, Kjaer, Magnus, Collén, Anna, Thompson, James D., Joyal, John, Chialda, Ligia, Koernicke, Thomas, Fuhr, Rainard, Chien, Kenneth R., Fritsche-Danielson, Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382754/
https://www.ncbi.nlm.nih.gov/pubmed/30787295
http://dx.doi.org/10.1038/s41467-019-08852-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382754/
https://www.ncbi.nlm.nih.gov/pubmed/30787295
http://dx.doi.org/10.1038/s41467-019-08852-4

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