Cargando…

Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways

Metastasis is one of the main causes of mortality in cancer patients. Inotilone, a major component of Inonotus linteus, is a traditional Chinese medical herb. In this study, MTT results showed that inotilone had no obvious cytotoxicity. Animal model results revealed that inotilone suppressed cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chao, Wei, Deng, Jeng-Shyan, Li, Pei-Ying, Kuo, Yueh-Hsiung, Huang, Guan-Jhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382761/ https://www.ncbi.nlm.nih.gov/pubmed/30787353 http://dx.doi.org/10.1038/s41598-019-38959-z

Ejemplares similares

Anti-Inflammatory Activities of Inotilone from Phellinus linteus through the Inhibition of MMP-9, NF-κB, and MAPK Activation In Vitro and In Vivo
por: Huang, Guan-Jhong, et al.
Publicado: (2012)

3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFκB Signaling Pathways
por: Chao, Wei, et al.
Publicado: (2017)

Actinidia callosa var. callosa suppresses metastatic potential of human hepatoma cell SK-Hep1 by inhibiting matrix metalloproteinase-2 through PI3K/Akt and MAPK signaling pathways
por: Deng, Jeng-Shyan, et al.
Publicado: (2018)

Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity
por: Fang, Jun, et al.
Publicado: (2020)

Ginsenoside Rh2 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the TLR4/PI3K/Akt/mTOR, Raf-1/MEK/ERK, and Keap1/Nrf2/HO-1 Signaling Pathways in Mice
por: Hsieh, Yung-Hung, et al.
Publicado: (2018)

Renoprotective Effect of Pediococcus acidilactici GKA4 on Cisplatin-Induced Acute Kidney Injury by Mitigating Inflammation and Oxidative Stress and Regulating the MAPK, AMPK/SIRT1/NF-κB, and PI3K/AKT Pathways
por: Lin, Wen-Hsin, et al.
Publicado: (2022)

Water Extract from Brown Strain of Flammulina velutipes Alleviates Cisplatin-Induced Acute Kidney Injury by Attenuating Oxidative Stress, Inflammation, and Autophagy via PI3K/AKT Pathway Regulation
por: Chou, Ya-Ni, et al.
Publicado: (2023)

Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy
por: Huang, Ching-Ying, et al.
Publicado: (2020)

Sanghuangporus sanghuang Mycelium Prevents Paracetamol-Induced Hepatotoxicity through Regulating the MAPK/NF-κB, Keap1/Nrf2/HO-1, TLR4/PI3K/Akt, and CaMKKβ/LKB1/AMPK Pathways and Suppressing Oxidative Stress and Inflammation
por: Jiang, Wen-Ping, et al.
Publicado: (2021)

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus
por: Huang, Shiow-Chyn, et al.
Publicado: (2018)

New Inonotus Polysaccharides: Characterization and Anticomplementary Activity of Inonotus rheades Mycelium Polymers
por: Olennikov, Daniil N., et al.
Publicado: (2023)

Artificial Cultivation Characteristics and Bioactive Effects of Novel Tropicoporus linteus (Syn. Phellinus linteus) Strains HN00K9 and HN6036 in Korea
por: Min, Gyeong-Jin, et al.
Publicado: (2021)

Caffeic Acid Derivatives Inhibit the Growth of Colon Cancer: Involvement of the PI3-K/Akt and AMPK Signaling Pathways
por: Chiang, En-Pei Isabel, et al.
Publicado: (2014)

Deoxypodophyllotoxin Induces ROS-Mediated Apoptosis by Modulating the PI3K/AKT and p38 MAPK-Dependent Signaling in Oral Squamous Cell Carcinoma
por: Seo, Ji-Hye, et al.
Publicado: (2022)

The Role of PI3K/AKT and MAPK Signaling Pathways in Erythropoietin Signalization
por: Tóthová, Zuzana, et al.
Publicado: (2021)

Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling
por: Sliva, D, et al.
Publicado: (2008)

Preventive Effects of Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways
por: Chang, Jui-Shu, et al.
Publicado: (2018)

Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus
por: Yeom, Ji-Hee, et al.
Publicado: (2012)

Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus
por: Hwang, Byung Soon, et al.
Publicado: (2014)

The bioavailability of red ginseng extract fermented by Phellinus linteus
por: Ryu, Jae Sik, et al.
Publicado: (2013)

Submerged Culture of Phellinus linteus for Mass Production of Polysaccharides
por: Lee, June Woo, et al.
Publicado: (2008)

A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus
por: Chen, Wenhua, et al.
Publicado: (2019)

Immunomodulatory and anti-inflammatory effects of Phellinus linteus mycelium
por: Shin, Mi-Rae, et al.
Publicado: (2021)

Ugonin M, a Helminthostachys zeylanica Constituent, Prevents LPS-Induced Acute Lung Injury through TLR4-Mediated MAPK and NF-κB Signaling Pathways
por: Wu, Kun-Chang, et al.
Publicado: (2017)

Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways
por: Hao, Wenjin, et al.
Publicado: (2015)

Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms
por: Su, Xi, et al.
Publicado: (2019)

TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway
por: Song, Guohe, et al.
Publicado: (2016)

Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
por: Pappalardo, Francesco, et al.
Publicado: (2016)

Melanins of Inonotus Obliquus: Bifidogenic and Antioxidant Properties
por: Burmasova, Marina A., et al.
Publicado: (2019)

Systemic Inonotus sp. Infection in a dog
por: FURUSAWA, Yu, et al.
Publicado: (2020)

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway
por: Cao, Wen-qiang, et al.
Publicado: (2019)

New Anti-inflammatory Flavonol Glycosides from Lindera akoensis Hayata
por: Yang, Chung-Ping, et al.
Publicado: (2019)

Sinensol-C Isolated from Spiranthes sinensis Inhibits Adipogenesis in 3T3-L1 Cells through the Regulation of Adipogenic Transcription Factors and AMPK Activation
por: Shie, Pei-Hsin, et al.
Publicado: (2020)

Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer
por: Collins, L, et al.
Publicado: (2006)

Anti-cancer Activities of Ginseng Extract Fermented with Phellinus linteus
por: Lee, Jong-Jin, et al.
Publicado: (2009)

Effect of Phellius linteus water extract on benign prostatic hyperplasia
por: Kim, Yu-Na, et al.
Publicado: (2013)

Chemical Constituents of the Culture Broth of Phellinus linteus and Their Antioxidant Activity
por: Lee, Myeong-Seok, et al.
Publicado: (2015)

Vasodilatory Effect of Phellinus linteus Extract in Rat Mesenteric Arteries
por: Kwon, Youngin, et al.
Publicado: (2020)

Chlorpyrifos induces male infertility in pigs through ROS and PI3K-AKT pathway
por: Zhang, Xuelian, et al.
Publicado: (2023)

p38 MAPK and PI3K/AKT Signalling Cascades inParkinson’s Disease
por: Jha, Saurabh Kumar, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ctbnivej4pl3q7vb42cttvqgg2