Cargando…

Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction

Serine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reaction that converts serine to glycine. It plays an important role in one-carbon metabolism. Recently, SHMT has been shown to be associated with various diseases. Therefore, SHMT has attracted attention as a biomarker and drug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nonaka, Hiroshi, Nakanishi, Yuki, Kuno, Satoshi, Ota, Tomoki, Mochidome, Kentaro, Saito, Yutaro, Sugihara, Fuminori, Takakusagi, Yoichi, Aoki, Ichio, Nagatoishi, Satoru, Tsumoto, Kouhei, Sando, Shinsuke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382819/ https://www.ncbi.nlm.nih.gov/pubmed/30787298 http://dx.doi.org/10.1038/s41467-019-08833-7

Ejemplares similares

Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate
por: Ota, Tomoki, et al.
Publicado: (2021)

Comparison of L-Threonine Aldolase Variants in the Aldol and Retro-Aldol Reactions
por: Fesko, Kateryna
Publicado: (2019)

Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
por: Pornthanakasem, Wichai, et al.
Publicado: (2012)

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
por: Senoo, Akinobu, et al.
Publicado: (2021)

Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori
por: Sodolescu, Andreea, et al.
Publicado: (2018)

Determinants of Thermostability in Serine Hydroxymethyltransferase Identified by Principal Component Analysis
por: Leng, Fei, et al.
Publicado: (2017)

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma
por: Clark, Rachael A., et al.
Publicado: (2022)

Managing the retro-pathway in direct catalytic asymmetric aldol reactions of thioamides
por: Bao, Youmei, et al.
Publicado: (2015)

The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism
por: Guiducci, Giulia, et al.
Publicado: (2019)

Chloroplastic Serine Hydroxymethyltransferase From Medicago truncatula: A Structural Characterization
por: Ruszkowski, Milosz, et al.
Publicado: (2018)

Roles of Mitochondrial Serine Hydroxymethyltransferase 2 (SHMT2) in Human Carcinogenesis
por: Zeng, Yuanyuan, et al.
Publicado: (2021)

Characterization of thermostable serine hydroxymethyltransferase for β-hydroxy amino acids synthesis
por: Ma’ruf, Ilma Fauziah, et al.
Publicado: (2022)

Discovery of chemical probes that suppress Wnt/β‐catenin signaling through high‐throughput screening
por: Yamaguchi, Kiyoshi, et al.
Publicado: (2020)

Serine hydroxymethyltransferase controls blood-meal digestion in the midgut of Aedes aegypti mosquitoes
por: Li, Xuemei, et al.
Publicado: (2019)

Exploring the Cold-Adaptation Mechanism of Serine Hydroxymethyltransferase by Comparative Molecular Dynamics Simulations
por: Zhang, Zhi-Bi, et al.
Publicado: (2021)

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy
por: Pikman, Yana, et al.
Publicado: (2021)

Serine Hydroxymethyltransferase 1 Is Essential for Primary-Root Growth at Low-Sucrose Conditions
por: Yuan, Yang, et al.
Publicado: (2022)

Design of a (15)N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State
por: Nonaka, Hiroshi, et al.
Publicado: (2017)

A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells
por: Eguchi, Akihiro, et al.
Publicado: (2021)

Positive correlation between expression level of mitochondrial serine hydroxymethyltransferase and breast cancer grade
por: Yin, Ke
Publicado: (2015)

Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma
por: Woo, Chern Chiuh, et al.
Publicado: (2016)

High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients
por: Shi, Haihong, et al.
Publicado: (2019)

Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models
por: Ruszkowski, Milosz, et al.
Publicado: (2019)

Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction
por: Di Salvo, Martino L., et al.
Publicado: (2013)

Characterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae
por: De Benedetti, Stefania, et al.
Publicado: (2014)

Soybean Cyst Nematode Resistance Emerged via Artificial Selection of Duplicated Serine Hydroxymethyltransferase Genes
por: Wu, Xiao-Yi, et al.
Publicado: (2016)

A Retro-Aldol Reaction Prompted the Evolvability of a Phosphotransferase System for the Utilization of a Rare Sugar
por: Joo, Yunhye, et al.
Publicado: (2023)

Use of molecular beacons to verify that the serine hydroxymethyltransferase pseudogene SHMT-ps1 is unique to the order Primates
por: Devor, Eric J
Publicado: (2001)

The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities
por: Chitnumsub, Penchit, et al.
Publicado: (2014)

A novel serine hydroxymethyltransferase from Arthrobacter nicotianae: characterization and improving catalytic efficiency by rational design
por: Jiang, Wei, et al.
Publicado: (2014)

Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity
por: Bouzidi, Amani, et al.
Publicado: (2020)

Insights Into the Known (13)C Depletion of Methane—Contribution of the Kinetic Isotope Effects on the Serine Hydroxymethyltransferase Reaction
por: Gleixner, Gerd
Publicado: (2022)

Genome-wide identification and expression analysis of serine hydroxymethyltransferase (SHMT) gene family in tomato (Solanum lycopersicum)
por: Liu, Zesheng, et al.
Publicado: (2022)

Serine hydroxymethyltransferase 2 predicts unfavorable outcomes in multiple cancer: a systematic review and meta-analysis
por: Du, Juan, et al.
Publicado: (2022)

In Silico and In Vitro Potential of FDA-Approved Drugs for Antimalarial Drug Repurposing against Plasmodium Serine Hydroxymethyltransferases
por: Mee-udorn, Pitchayathida, et al.
Publicado: (2023)

Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography
por: Drago, Victoria N., et al.
Publicado: (2023)

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition
por: Takahashi, Tomoya, et al.
Publicado: (2018)

Raman Spectroscopic Analysis of Highly-Concentrated Antibodies under the Acid-Treated Conditions
por: Sato, Yusui, et al.
Publicado: (2023)

Efficient Conversion of Glucose to Methyl Lactate with Sn-USY: Retro-aldol Activity Promotion by Controlled Ion Exchange
por: Jimenez-Martin, Jose M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ek8tenl3kv5n94fpoqb9iqolog