Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use

Spread of antimicrobial resistance and shortage of novel antibiotics have led to an urgent need for new antibacterials. Although aminoglycoside antibiotics (AGs) are very potent anti-infectives, their use is largely restricted due to serious side-effects, mainly nephrotoxicity and ototoxicity. We ev...

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Detalles Bibliográficos
Autores principales: Ishikawa, Masaaki, García-Mateo, Nadia, Čusak, Alen, López-Hernández, Iris, Fernández-Martínez, Marta, Müller, Marcus, Rüttiger, Lukas, Singer, Wibke, Löwenheim, Hubert, Kosec, Gregor, Fujs, Štefan, Martínez-Martínez, Luis, Schimmang, Thomas, Petković, Hrvoje, Knipper, Marlies, Durán-Alonso, M. Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382871/
https://www.ncbi.nlm.nih.gov/pubmed/30787404
http://dx.doi.org/10.1038/s41598-019-38634-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382871/
https://www.ncbi.nlm.nih.gov/pubmed/30787404
http://dx.doi.org/10.1038/s41598-019-38634-3

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