Exosite 1 thrombin inhibition with JNJ-64179375 inhibits thrombus formation in a human translational model of thrombosis

AIMS: JNJ-64179375 (hereafter JNJ-9375) is a first-in-class, highly specific, large molecule, exosite 1 thrombin inhibitor. In preclinical studies, JNJ-9375 demonstrated robust antithrombotic protection with a wider therapeutic index when compared to apixaban. The purpose of the present study was to...

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Detalles Bibliográficos
Autores principales: Wilson, Simon J, Connolly, Thomas M, Peters, Gary, Ghosh, Atalanta, Johnson, Maureen, Newby, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383059/
https://www.ncbi.nlm.nih.gov/pubmed/30184110
http://dx.doi.org/10.1093/cvr/cvy227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383059/
https://www.ncbi.nlm.nih.gov/pubmed/30184110
http://dx.doi.org/10.1093/cvr/cvy227

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