Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons

Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect that cocaine directly inhibits α6N/α3Cβ2β3-nAChR (α6*-nAChRs)...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Dejie, Gao, Fenfei, Ma, Xiaokuang, Eaton, Jason Brek, Huang, Yuanbing, Gao, Ming, Chang, Yongchang, Ma, Zegang, Der-Ghazarian, Taleen, Neisewander, Janet, Whiteaker, Paul, Wu, Jie, Su, Quanxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383119/
https://www.ncbi.nlm.nih.gov/pubmed/30837868
http://dx.doi.org/10.3389/fphar.2019.00072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383119/
https://www.ncbi.nlm.nih.gov/pubmed/30837868
http://dx.doi.org/10.3389/fphar.2019.00072

Ejemplares similares