Cargando…

Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons

Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect that cocaine directly inhibits α6N/α3Cβ2β3-nAChR (α6*-nAChRs)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Dejie, Gao, Fenfei, Ma, Xiaokuang, Eaton, Jason Brek, Huang, Yuanbing, Gao, Ming, Chang, Yongchang, Ma, Zegang, Der-Ghazarian, Taleen, Neisewander, Janet, Whiteaker, Paul, Wu, Jie, Su, Quanxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383119/ https://www.ncbi.nlm.nih.gov/pubmed/30837868 http://dx.doi.org/10.3389/fphar.2019.00072

Ejemplares similares

Cocaine potently blocks neuronal α(3)β(4) nicotinic acetylcholine receptors in SH-SY5Y cells
por: Ma, Ze-gang, et al.
Publicado: (2019)

Mechanisms of cannabinoid CB(2) receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area
por: Ma, Zegang, et al.
Publicado: (2019)

Pharmacological Evidence for an Abstinence-Induced Switch in 5-HT(1B) Receptor Modulation of Cocaine Self-Administration and Cocaine-Seeking Behavior
por: Pentkowski, Nathan S., et al.
Publicado: (2013)

Effects of a 5-HT(1B) Receptor Agonist on Locomotion and Reinstatement of Cocaine-Conditioned Place Preference after Abstinence from Repeated Injections in Mice
por: Der-Ghazarian, Taleen S., et al.
Publicado: (2017)

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes
por: Kassner, Michelle, et al.
Publicado: (2022)

Addendum: Effects of a 5-HT(1B) Receptor Agonist on Locomotion and Reinstatement of Cocaine-Conditioned Place Preference after Abstinence from Repeated Injections in Mice
por: Der-Ghazarian, Taleen S., et al.
Publicado: (2018)

NMDA Receptors on Non-Dopaminergic Neurons in the VTA Support Cocaine Sensitization
por: Luo, Yu, et al.
Publicado: (2010)

VTA BDNF enhances social stress-induced compulsive cocaine bingeing
por: Wang, Junshi, et al.
Publicado: (2016)

The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile
por: Yu, Li-Fang, et al.
Publicado: (2014)

Repeated social defeat stress enhances glutamatergic synaptic plasticity in the VTA and cocaine place conditioning
por: Stelly, Claire E, et al.
Publicado: (2016)

Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc
por: Salin, Adélie, et al.
Publicado: (2020)

Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice
por: Wang, Lun, et al.
Publicado: (2023)

Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?
por: Wolf, Marina E., et al.
Publicado: (2012)

Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs)
por: Li, Yan, et al.
Publicado: (2017)

Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure
por: Moulin, Thiago C., et al.
Publicado: (2020)

Recent Developments in Novel Antidepressants Targeting α4β2-Nicotinic Acetylcholine Receptors: Miniperspective
por: Yu, Li-Fang, et al.
Publicado: (2014)

GLP-1 receptor signaling in the laterodorsal tegmental nucleus attenuates cocaine seeking by activating GABAergic circuits that project to the VTA
por: Hernandez, Nicole S., et al.
Publicado: (2020)

Apigenin and Structurally Related Flavonoids Allosterically Potentiate the Function of Human α7-Nicotinic Acetylcholine Receptors Expressed in SH-EP1 Cells
por: Shabbir, Waheed, et al.
Publicado: (2021)

Cocaine inhibition of nicotinic acetylcholine receptors influences dopamine release
por: Acevedo-Rodriguez, Alexandra, et al.
Publicado: (2014)

Cooperative CRF and α1 Adrenergic Signaling in the VTA Promotes NMDA Plasticity and Drives Social Stress Enhancement of Cocaine Conditioning
por: Tovar-Díaz, Jorge, et al.
Publicado: (2018)

VtaA8 and VtaA9 from Haemophilus parasuis delay phagocytosis by alveolar macrophages
por: Costa-Hurtado, Mar, et al.
Publicado: (2012)

The Lateral Preoptic Area and Its Projection to the VTA Regulate VTA Activity and Drive Complex Reward Behaviors
por: Gordon-Fennell, Adam, et al.
Publicado: (2020)

From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue
por: Bavo, Francesco, et al.
Publicado: (2022)

Commentary: Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice
por: Morley, Barbara J., et al.
Publicado: (2018)

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions()
por: Whiteaker, Paul, et al.
Publicado: (2023)

Acetylcholine signaling genes are required for cocaine-stimulated egg laying in Caenorhabditis elegans
por: Emerson, Soren, et al.
Publicado: (2021)

The Role of Dopaminergic VTA Neurons in General Anesthesia
por: Zhou, Xuelong, et al.
Publicado: (2015)

Periaqueductal efferents to dopamine and GABA neurons of the VTA
por: Ntamati, Niels R., et al.
Publicado: (2018)

VTA GABA Neurons at the Interface of Stress and Reward
por: Bouarab, Chloé, et al.
Publicado: (2019)

Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development
por: Xia, Hengchuan, et al.
Publicado: (2017)

Neurotoxin-Induced Pathway Perturbation in Human Neuroblastoma SH-EP Cells
por: Do, Jin Hwan
Publicado: (2014)

Preclinical support for the therapeutic potential of zolmitriptan as a treatment for cocaine use disorders
por: Garcia, Raul, et al.
Publicado: (2020)

Distinctive single-channel properties of α4β2-nicotinic acetylcholine receptor isoforms
por: Weltzin, Maegan M., et al.
Publicado: (2019)

VTA-NAc glutaminergic projection involves in the regulation of pain and pain-related anxiety
por: Abdul, Mannan, et al.
Publicado: (2022)

VTA neurons coordinate with the hippocampal reactivation of spatial experience
por: Gomperts, Stephen N, et al.
Publicado: (2015)

Mechanisms for multiple activity modes of VTA dopamine neurons
por: Oster, Andrew, et al.
Publicado: (2015)

Correction: Periaqueductal efferents to dopamine and GABA neurons of the VTA
por: Ntamati, Niels R., et al.
Publicado: (2019)

Sexual congruency in the connectome and translatome of VTA dopamine neurons
por: Chung, Amanda S., et al.
Publicado: (2017)

Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits
por: Yan, Yijin, et al.
Publicado: (2019)

Systematic analysis of expression signatures of neuronal subpopulations in the VTA
por: Kim, Hyun Jin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0jabuv45v138tlifo0voigmnn4