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Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons

Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are potentially involved in drug reward and dependence. Here, we report a novel effect that cocaine directly inhibits α6N/α3Cβ2β3-nAChR (α6*-nAChRs)...

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Detalles Bibliográficos
Autores principales:	Chen, Dejie, Gao, Fenfei, Ma, Xiaokuang, Eaton, Jason Brek, Huang, Yuanbing, Gao, Ming, Chang, Yongchang, Ma, Zegang, Der-Ghazarian, Taleen, Neisewander, Janet, Whiteaker, Paul, Wu, Jie, Su, Quanxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383119/ https://www.ncbi.nlm.nih.gov/pubmed/30837868 http://dx.doi.org/10.3389/fphar.2019.00072

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