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New Conformations of Acylation Adducts of Inhibitors of β-Lactamase from Mycobacterium tuberculosis

[Image: see text] Mycobacterium tuberculosis (Mtb), the main causative agent of tuberculosis (TB), is naturally resistant to β-lactam antibiotics due to the production of the extended spectrum β-lactamase BlaC. β-Lactam/β-lactamase inhibitor combination therapies can circumvent the BlaC-mediated res...

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Detalles Bibliográficos
Autores principales:	Tassoni, Raffaella, Blok, Anneloes, Pannu, Navraj S., Ubbink, Marcellus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383187/ https://www.ncbi.nlm.nih.gov/pubmed/30632739 http://dx.doi.org/10.1021/acs.biochem.8b01085

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