Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft

Nimotuzumab is a humanized anti-epidermal growth factor receptor I (EGFR) monoclonal antibody. We have developed antibody drug conjugates (ADCs) with nimotuzumab conjugated to PEGylated-maytansine (PEG(6)-DM1). We generated conjugates with low (nimotuzumab-PEG(6)-DM1-Low: DAR = 3.5) and high (nimotu...

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Detalles Bibliográficos
Autores principales: Hartimath, Siddesh V., El-Sayed, Ayman, Makhlouf, Amal, Bernhard, Wendy, Gonzalez, Carolina, Hill, Wayne, Parada, Angel Casaco, Barreto, Kris, Geyer, Clarence Ronald, Fonge, Humphrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383682/
https://www.ncbi.nlm.nih.gov/pubmed/30800216
http://dx.doi.org/10.18632/oncotarget.26613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383682/
https://www.ncbi.nlm.nih.gov/pubmed/30800216
http://dx.doi.org/10.18632/oncotarget.26613

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