TGF‐β Initiates β‐Catenin‐Mediated CTGF Secretory Pathway in Old Bovine Nucleus Pulposus Cells: A Potential Mechanism for Intervertebral Disc Degeneration

We have recently demonstrated that overexpression of Smurf2 under the control of type II collagen alpha 1 (Col2a1) promoter induces an intervertebral disc degeneration phenotype in Col2a1‐Smurf2 transgenic mice. The chondrocyte‐like cells that express type II collagen and Smurf2 in the transgenic mo...

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Detalles Bibliográficos
Autores principales: Wu, Qiuqian, Mathers, Chun, Wang, Ernest W, Sheng, Sen, Wenkert, David, Huang, Jason H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383704/
https://www.ncbi.nlm.nih.gov/pubmed/30828686
http://dx.doi.org/10.1002/jbm4.10069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383704/
https://www.ncbi.nlm.nih.gov/pubmed/30828686
http://dx.doi.org/10.1002/jbm4.10069

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