Sexually dimorphic tumor suppression by small mitochondrial Arf

Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in...

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Detalles Bibliográficos
Autores principales: van Oosterwijk, Jolieke G., Tillman, Heather, Sherr, Charles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Priority Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383814/
https://www.ncbi.nlm.nih.gov/pubmed/30815226
http://dx.doi.org/10.18632/oncotarget.26651
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author van Oosterwijk, Jolieke G.
Tillman, Heather
Sherr, Charles J.
author_facet van Oosterwijk, Jolieke G.
Tillman, Heather
Sherr, Charles J.
author_sort van Oosterwijk, Jolieke G.
collection PubMed
description Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in lieu of the full-length Arf protein retain residual, sexually dimorphic tumor suppressive activity.
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spelling pubmed-63838142019-02-27 Sexually dimorphic tumor suppression by small mitochondrial Arf van Oosterwijk, Jolieke G. Tillman, Heather Sherr, Charles J. Oncotarget Priority Research Perspective Internal translational initiation of the mRNA encoding the Arf tumor suppressor yields an N-terminally truncated small Arf protein (smArf) that lacks amino acid residues required for Mdm2 binding and p53 activation. Here, we report that female, but not male, mice engineered to produce only smArf in lieu of the full-length Arf protein retain residual, sexually dimorphic tumor suppressive activity. Impact Journals LLC 2019-02-08 /pmc/articles/PMC6383814/ /pubmed/30815226 http://dx.doi.org/10.18632/oncotarget.26651 Text en Copyright: © 2019 van Oosterwijk et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Priority Research Perspective
van Oosterwijk, Jolieke G.
Tillman, Heather
Sherr, Charles J.
Sexually dimorphic tumor suppression by small mitochondrial Arf
title Sexually dimorphic tumor suppression by small mitochondrial Arf
title_full Sexually dimorphic tumor suppression by small mitochondrial Arf
title_fullStr Sexually dimorphic tumor suppression by small mitochondrial Arf
title_full_unstemmed Sexually dimorphic tumor suppression by small mitochondrial Arf
title_short Sexually dimorphic tumor suppression by small mitochondrial Arf
title_sort sexually dimorphic tumor suppression by small mitochondrial arf
topic Priority Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383814/
https://www.ncbi.nlm.nih.gov/pubmed/30815226
http://dx.doi.org/10.18632/oncotarget.26651
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