FGF2-FGFR1 pathway activation together with thymidylate synthase upregulation is induced in pemetrexed-resistant lung cancer cells

Pemetrexed (MTA) is a folate antimetabolite used for treating non-small cell lung cancer. To elucidate the mechanisms of pemetrexed resistance in lung cancer, we established pemetrexed-resistant sublines in PC9 (mutant EGFR) and H1993 (wild-type EGFR) lung adenocarcinoma cell lines (PC9-MTA, H1993-M...

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Detalles Bibliográficos
Autores principales: Miura, Kentaro, Oba, Takaaki, Hamanaka, Kazutoshi, Ito, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383826/
https://www.ncbi.nlm.nih.gov/pubmed/30838090
http://dx.doi.org/10.18632/oncotarget.26622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383826/
https://www.ncbi.nlm.nih.gov/pubmed/30838090
http://dx.doi.org/10.18632/oncotarget.26622

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