Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage

NSMCE2 is an E3 SUMO ligase and a subunit of the SMC5/6 complex that associates with the replication fork and protects against genomic instability. Here, we study the fate of collapsed replication forks generated by prolonged hydroxyurea treatment in human NSMCE2-deficient cells. Double strand break...

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Detalles Bibliográficos
Autores principales: Pond, Kelvin W., de Renty, Christelle, Yagle, Mary K., Ellis, Nathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383951/
https://www.ncbi.nlm.nih.gov/pubmed/30735491
http://dx.doi.org/10.1371/journal.pgen.1007942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383951/
https://www.ncbi.nlm.nih.gov/pubmed/30735491
http://dx.doi.org/10.1371/journal.pgen.1007942

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