Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-β-Naphthylamide from Random Mutagenesis

Phe-Arg-β-naphthylamide (PAβN) has been characterized as an efflux pump inhibitor (EPI) acting on the major multidrug resistance efflux transporters of Gram-negative bacteria, such as AcrB in Eschericha coli. In the present study, in vitro random mutagenesis was used to evolve resistance to the sens...

Descripción completa

Detalles Bibliográficos
Autores principales: Schuster, Sabine, Bohnert, Jürgen A., Vavra, Martina, Rossen, John W., Kern, Winfried V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384556/
https://www.ncbi.nlm.nih.gov/pubmed/30699887
http://dx.doi.org/10.3390/molecules24030470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384556/
https://www.ncbi.nlm.nih.gov/pubmed/30699887
http://dx.doi.org/10.3390/molecules24030470

Ejemplares similares