Cargando…

Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-β-Naphthylamide from Random Mutagenesis

Phe-Arg-β-naphthylamide (PAβN) has been characterized as an efflux pump inhibitor (EPI) acting on the major multidrug resistance efflux transporters of Gram-negative bacteria, such as AcrB in Eschericha coli. In the present study, in vitro random mutagenesis was used to evolve resistance to the sens...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schuster, Sabine, Bohnert, Jürgen A., Vavra, Martina, Rossen, John W., Kern, Winfried V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384556/ https://www.ncbi.nlm.nih.gov/pubmed/30699887 http://dx.doi.org/10.3390/molecules24030470

Ejemplares similares

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria
por: Lamers, Ryan P., et al.
Publicado: (2013)

Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli
por: Bohnert, Jürgen A, et al.
Publicado: (2013)

Determination of Real-Time Efflux Phenotypes in Escherichia coli AcrB Binding Pocket Phenylalanine Mutants Using a 1,2′-Dinaphthylamine Efflux Assay
por: Bohnert, Jürgen A., et al.
Publicado: (2011)

Exploring the Contribution of the AcrB Homolog MdtF to Drug Resistance and Dye Efflux in a Multidrug Resistant E. coli Isolate
por: Schuster, Sabine, et al.
Publicado: (2021)

Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant Escherichia coli by Efflux Pump Inhibition Coupled with Outer Membrane Permeabilization Induced by Phenylalanine-Arginine β-Naphthylamide
por: Al-Marzooq, Farah, et al.
Publicado: (2023)

Sono-Assembly of the [Arg-Phe](4) Octapeptide into Biofunctional Nanoparticles
por: Baral, Anshul, et al.
Publicado: (2020)

pheS(AG) Based Rapid and Efficient Markerless Mutagenesis in Methylotuvimicrobium
por: Liu, Yongchuang, et al.
Publicado: (2020)

Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons
por: Kelestimur, Haluk, et al.
Publicado: (2013)

Mutagenesis of the rpoS gene involved in alteration of outer membrane composition
por: Rahpeyma, Sayyed Shahryar, et al.
Publicado: (2019)

Phe-Met-Arg-Phe-amide Activates a Novel Voltage-dependent K(+) Current through a Lipoxygenase Pathway in Molluscan Neurones
por: Kits, K.S., et al.
Publicado: (1997)

Knockout of an outer membrane protein operon of Anaplasma marginale by transposon mutagenesis
por: Crosby, Francy L, et al.
Publicado: (2014)

Coronavirus IBV: Partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41
por: Cavanagh, David, et al.
Publicado: (1986)

Rational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors
por: Figueiredo, Ana C., et al.
Publicado: (2012)

Phenylalanine-arginine β-naphthylamide could enhance neomycin-sensitivity on Riemerella anatipestifer in vitro and in vivo
por: Liu, Shiqi, et al.
Publicado: (2023)

Efflux Pump Inhibitor Phenylalanine-Arginine Β-Naphthylamide Effect on the Minimum Inhibitory Concentration of Imipenem in Acinetobacter baumannii Strains Isolated From Hospitalized Patients in Shahid Motahari Burn Hospital, Tehran, Iran
por: Gholami, Mehrdad, et al.
Publicado: (2015)

Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner
por: Janganan, Thamarai K., et al.
Publicado: (2011)

Improvement in the Histochemical Localization of Leucine Aminopeptidase with a New Substrate, L-Leucyl-4-Methoxy-2-Naphthylamide
por: Nachlas, Marvin M., et al.
Publicado: (1960)

Effect of azithromycin and phenylalanine-arginine beta-naphthylamide on quorum sensing and virulence factors in clinical isolates of Pseudomonas aeruginosa
por: Elsheredy, Amel, et al.
Publicado: (2021)

Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump
por: Janganan, Thamarai K, et al.
Publicado: (2013)

Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies
por: Phan, Gilles, et al.
Publicado: (2015)

Clonality, outer-membrane proteins profile and efflux pump in KPC- producing Enterobacter sp. in Brazil
por: Rosa, Juliana Ferraz, et al.
Publicado: (2017)

A noncanonical chaperone interacts with drug efflux pumps during their assembly into bacterial outer membranes
por: Stubenrauch, Christopher J., et al.
Publicado: (2022)

Importance of Solvent-Bridged Structures of Fluorinated Diphenylalanines: Synthesis, Detailed NMR Analysis, and Rotational Profiles of Phe(2-F)-Phe(2-F), Phe(2-F)-Phe, and Phe-Phe(2-F)
por: Yang, Kaidi, et al.
Publicado: (2022)

Effect of Phenylalanine–Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii
por: Plasencia-Rebata, Stefany, et al.
Publicado: (2023)

The Phe-Phe Motif for Peptide Self-Assembly in Nanomedicine
por: Marchesan, Silvia, et al.
Publicado: (2015)

Heterochirality and Halogenation Control Phe-Phe Hierarchical Assembly
por: Kralj, Slavko, et al.
Publicado: (2020)

Crystal Structure of Escherichia coli CusC, the Outer Membrane Component of a Heavy Metal Efflux Pump
por: Kulathila, Rithika, et al.
Publicado: (2011)

Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria
por: Krishnamoorthy, Ganesh, et al.
Publicado: (2017)

Penetration through Outer Membrane and Efflux Potential in Pseudomonas aeruginosa of Bulgecin A as an Adjuvant to β-Lactam Antibiotics
por: Kim, Choon, et al.
Publicado: (2023)

AcrB Trimer Stability and Efflux Activity, Insight from Mutagenesis Studies
por: Yu, Linliang, et al.
Publicado: (2011)

Probing the Role of the Conserved Arg174 in Formate Dehydrogenase by Chemical Modification and Site-Directed Mutagenesis
por: Alqarni, Mohammed Hamed, et al.
Publicado: (2021)

Non‐pulmonary CFTR‐related symptom improvement with ivacaftor in p.Phe508del/p.Arg117His (7T) cystic fibrosis
por: Kuek, Stephanie L., et al.
Publicado: (2022)

ICTR-PHE 2016
por: Brice, Maximilien
Publicado: (2016)

ICTR-PHE 2014
por: Pantelia, Anna
Publicado: (2014)

Phe–Phe Di-Peptide Nanostructure Self-Assembling Modulated by Luminescent Additives
por: Ribeiro, Antonio C. C., et al.
Publicado: (2019)

The Role of Active-Site Residues Phe98, His239, and Arg243 in DNA Binding and in the Catalysis of Human Uracil–DNA Glycosylase SMUG1
por: Iakovlev, Danila A., et al.
Publicado: (2019)

Crystal structure of an antigenic outer-membrane protein from Salmonella Typhi suggests a potential antigenic loop and an efflux mechanism
por: Guan, Hong-Hsiang, et al.
Publicado: (2015)

Modifying ICCA with Trp-Phe-Phe to Enhance in vivo Activity and Form Nano-Medicine
por: Zhang, Xiaoyi, et al.
Publicado: (2020)

Membrane Remodeling by Arc/Arg3.1
por: Hedde, Per Niklas, et al.
Publicado: (2021)

Bark extract of Cassia sieberiana DC. (Caesalpiniaceae) displayed good antibacterial activity against MDR gram-negative phenotypes in the presence of phenylalanine-arginine β-naphthylamide
por: Ambadiang, Marilene M. M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_unfi1cl9do90n6eold7clcge3d