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Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction

G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G...

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Autores principales: Sun, Zhi-Yin, Wang, Xiao-Na, Cheng, Sui-Qi, Su, Xiao-Xuan, Ou, Tian-Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384609/
https://www.ncbi.nlm.nih.gov/pubmed/30678288
http://dx.doi.org/10.3390/molecules24030396
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author Sun, Zhi-Yin
Wang, Xiao-Na
Cheng, Sui-Qi
Su, Xiao-Xuan
Ou, Tian-Miao
author_facet Sun, Zhi-Yin
Wang, Xiao-Na
Cheng, Sui-Qi
Su, Xiao-Xuan
Ou, Tian-Miao
author_sort Sun, Zhi-Yin
collection PubMed
description G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized.
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spelling pubmed-63846092019-02-23 Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction Sun, Zhi-Yin Wang, Xiao-Na Cheng, Sui-Qi Su, Xiao-Xuan Ou, Tian-Miao Molecules Review G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of genome. G-quadruplexes have been proved to be involved in the regulation of replication, DNA damage repair, and transcription and translation of oncogenes or other cancer-related genes. Therefore, targeting G-quadruplexes has become a novel promising anti-tumor strategy. Different kinds of small molecules targeting the G-quadruplexes have been designed, synthesized, and identified as potential anti-tumor agents, including molecules directly bind to the G-quadruplex and molecules interfering with the binding between the G-quadruplex structures and related binding proteins. This review will explore the feasibility of G-quadruplex ligands acting as anti-tumor drugs, from basis to application. Meanwhile, since helicase is the most well-defined G-quadruplex-related protein, the most extensive research on the relationship between helicase and G-quadruplexes, and its meaning in drug design, is emphasized. MDPI 2019-01-22 /pmc/articles/PMC6384609/ /pubmed/30678288 http://dx.doi.org/10.3390/molecules24030396 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Zhi-Yin
Wang, Xiao-Na
Cheng, Sui-Qi
Su, Xiao-Xuan
Ou, Tian-Miao
Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
title Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
title_full Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
title_fullStr Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
title_full_unstemmed Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
title_short Developing Novel G-Quadruplex Ligands: From Interaction with Nucleic Acids to Interfering with Nucleic Acid–Protein Interaction
title_sort developing novel g-quadruplex ligands: from interaction with nucleic acids to interfering with nucleic acid–protein interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384609/
https://www.ncbi.nlm.nih.gov/pubmed/30678288
http://dx.doi.org/10.3390/molecules24030396
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