Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles

New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral compounds were separated into their single enantiomers and tested. The impact of the...

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Detalles Bibliográficos
Autores principales: Guglielmi, Paolo, Carradori, Simone, Poli, Giulio, Secci, Daniela, Cirilli, Roberto, Rotondi, Giulia, Chimenti, Paola, Petzer, Anél, Petzer, Jacobus P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384781/
https://www.ncbi.nlm.nih.gov/pubmed/30700029
http://dx.doi.org/10.3390/molecules24030484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384781/
https://www.ncbi.nlm.nih.gov/pubmed/30700029
http://dx.doi.org/10.3390/molecules24030484

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