Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes

Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrP(C) into misfolded and aggregating PrP(Sc) is the central event in prion disease, an alternati...

Descripción completa

Detalles Bibliográficos
Autores principales: Czech, Andreas, Konarev, Petr V., Goebel, Ingrid, Svergun, Dmitri I., Wills, Peter R., Ignatova, Zoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384910/
https://www.ncbi.nlm.nih.gov/pubmed/30792490
http://dx.doi.org/10.1038/s41598-019-39213-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384910/
https://www.ncbi.nlm.nih.gov/pubmed/30792490
http://dx.doi.org/10.1038/s41598-019-39213-2

Ejemplares similares