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Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes

Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrP(C) into misfolded and aggregating PrP(Sc) is the central event in prion disease, an alternati...

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Detalles Bibliográficos
Autores principales:	Czech, Andreas, Konarev, Petr V., Goebel, Ingrid, Svergun, Dmitri I., Wills, Peter R., Ignatova, Zoya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384910/ https://www.ncbi.nlm.nih.gov/pubmed/30792490 http://dx.doi.org/10.1038/s41598-019-39213-2

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