One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions

A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.

Detalles Bibliográficos
Autores principales: Ma, Xiaoming, Zhang, Xiaofeng, Qiu, Weiqi, Zhang, Wensheng, Wan, Bruce, Evans, Jason, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384988/
https://www.ncbi.nlm.nih.gov/pubmed/30743991
http://dx.doi.org/10.3390/molecules24030601
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author Ma, Xiaoming
Zhang, Xiaofeng
Qiu, Weiqi
Zhang, Wensheng
Wan, Bruce
Evans, Jason
Zhang, Wei
author_facet Ma, Xiaoming
Zhang, Xiaofeng
Qiu, Weiqi
Zhang, Wensheng
Wan, Bruce
Evans, Jason
Zhang, Wei
author_sort Ma, Xiaoming
collection PubMed
description A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions.
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spelling pubmed-63849882019-02-23 One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions Ma, Xiaoming Zhang, Xiaofeng Qiu, Weiqi Zhang, Wensheng Wan, Bruce Evans, Jason Zhang, Wei Molecules Communication A one-pot synthesis of triazolobenzodiazepine-containing polycyclic compounds is introduced. The reaction process involves a decarboxylative three-component [3 + 2] cycloaddition of nonstabilized azomethine ylides, N-propargylation, and intramolecular click reactions. MDPI 2019-02-08 /pmc/articles/PMC6384988/ /pubmed/30743991 http://dx.doi.org/10.3390/molecules24030601 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ma, Xiaoming
Zhang, Xiaofeng
Qiu, Weiqi
Zhang, Wensheng
Wan, Bruce
Evans, Jason
Zhang, Wei
One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
title One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
title_full One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
title_fullStr One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
title_full_unstemmed One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
title_short One-Pot Synthesis of Triazolobenzodiazepines Through Decarboxylative [3 + 2] Cycloaddition of Nonstabilized Azomethine Ylides and Cu-Free Click Reactions
title_sort one-pot synthesis of triazolobenzodiazepines through decarboxylative [3 + 2] cycloaddition of nonstabilized azomethine ylides and cu-free click reactions
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384988/
https://www.ncbi.nlm.nih.gov/pubmed/30743991
http://dx.doi.org/10.3390/molecules24030601
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