A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-per...

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Autores principales: Arioli, Federica, Pérez, Maria, Are, Celeste, Molins, Elies, Bosch, Joan, Amat, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385050/
https://www.ncbi.nlm.nih.gov/pubmed/30717460
http://dx.doi.org/10.3390/molecules24030557
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author Arioli, Federica
Pérez, Maria
Are, Celeste
Molins, Elies
Bosch, Joan
Amat, Mercedes
author_facet Arioli, Federica
Pérez, Maria
Are, Celeste
Molins, Elies
Bosch, Joan
Amat, Mercedes
author_sort Arioli, Federica
collection PubMed
description Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones.
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spelling pubmed-63850502019-02-23 A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones Arioli, Federica Pérez, Maria Are, Celeste Molins, Elies Bosch, Joan Amat, Mercedes Molecules Article Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-perhydroisoquinolin-1-ones. MDPI 2019-02-03 /pmc/articles/PMC6385050/ /pubmed/30717460 http://dx.doi.org/10.3390/molecules24030557 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arioli, Federica
Pérez, Maria
Are, Celeste
Molins, Elies
Bosch, Joan
Amat, Mercedes
A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
title A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
title_full A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
title_fullStr A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
title_full_unstemmed A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
title_short A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
title_sort straightforward synthesis of functionalized cis-perhydroisoquinolin-1-ones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385050/
https://www.ncbi.nlm.nih.gov/pubmed/30717460
http://dx.doi.org/10.3390/molecules24030557
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