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A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides functionalized cis-per...

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Detalles Bibliográficos
Autores principales:	Arioli, Federica, Pérez, Maria, Are, Celeste, Molins, Elies, Bosch, Joan, Amat, Mercedes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385050/ https://www.ncbi.nlm.nih.gov/pubmed/30717460 http://dx.doi.org/10.3390/molecules24030557

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