Synthesis of a Conformationally Stable Atropisomeric Pair of Biphenyl Scaffold Containing Additional Stereogenic Centers

The synthesis of a new CF(3)-containing stereogenic atropisomeric pair of ortho-disubstituted biphenyl scaffold is presented. The atropisomers are surprisingly conformationally stable for isolation. X-ray structures show that their stability comes from an intramolecular hydrogen bond formation from...

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Detalles Bibliográficos
Autores principales: Yeung, Chi-Tung, Chan, Wesley Ting Kwok, Lo, Wai-Sum, Law, Ga-Lai, Wong, Wing-Tak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385101/
https://www.ncbi.nlm.nih.gov/pubmed/30759758
http://dx.doi.org/10.3390/molecules24030643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385101/
https://www.ncbi.nlm.nih.gov/pubmed/30759758
http://dx.doi.org/10.3390/molecules24030643

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