Cargando…

Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma

Characterized with a high recurrence rate and low detection rate, prevention is the best approach to reduce mortality in hepatocellular carcinoma (HCC). The overexpression of Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2 (PREX2) is observed in various tumors, including HCC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Ming-Hui, Yen, Chia-Hung, Chen, Yen-Fu, Fang, Cheng-Chieh, Li, Chung-Hsien, Lee, Kuo-Jui, Lin, Yi-Hsiung, Weng, Chien-Hui, Liu, Tze-Tze, Huang, Shiu-Feng, Teh, Bin Tean, Chen, Yi-Ming Arthur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385191/ https://www.ncbi.nlm.nih.gov/pubmed/30796242 http://dx.doi.org/10.1038/s41598-018-36810-5

Ejemplares similares

Knockdown of PREX2a inhibits the malignant phenotype of glioma cells
por: Liu, Liang, et al.
Publicado: (2021)

Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development
por: Yen, Chia-Hung, et al.
Publicado: (2017)

Melanoma genome sequencing reveals frequent PREX2 mutations
por: Berger, Michael F., et al.
Publicado: (2012)

MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma
por: Hung, Jung-Hsien, et al.
Publicado: (2018)

Nivolumab Versus Regorafenib in Patients With Hepatocellular Carcinoma After Sorafenib Failure
por: Kuo, Yuan-Hung, et al.
Publicado: (2021)

Knockdown of PREX2a inhibits the malignant phenotype of osteosarcoma cells
por: Dai, Zixun, et al.
Publicado: (2022)

Elevated levels of serum urokinase plasminogen activator predict poor prognosis in hepatocellular carcinoma after resection
por: Tsai, Ming-Chao, et al.
Publicado: (2019)

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma
por: Liao, Wen-Ying, et al.
Publicado: (2020)

Real-World Lenvatinib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis
por: Kuo, Yuan-Hung, et al.
Publicado: (2021)

Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes
por: Liu, Yen-Tze, et al.
Publicado: (2019)

Common Altered Epigenomic Domains in Cancer Cells: Characterization and Subtle Variations
por: Tsai, Yi-Chien, et al.
Publicado: (2011)

Registered report: Melanoma genome sequencing reveals frequent PREX2 mutations
por: Chroscinski, Denise, et al.
Publicado: (2014)

Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations
por: Horrigan, Stephen K, et al.
Publicado: (2017)

PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells
por: Clements, Miranda E., et al.
Publicado: (2019)

Corrigendum: Real-World Lenvatinib Versus Sorafenib in Patients With Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis
por: Kuo, Yuan-Hung, et al.
Publicado: (2021)

Utilizing proteomic approach to identify nuclear translocation related serine kinase phosphorylation site of GNMT as downstream effector for benzo[a]pyrene
por: Yang, Ming-Hui, et al.
Publicado: (2019)

Induction of GNMT by 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside through proteasome-independent MYC downregulation in hepatocellular carcinoma
por: Kant, Rajni, et al.
Publicado: (2019)

Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases
por: Huang, Yen-Chun, et al.
Publicado: (2020)

Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells
por: Yen, Jui-Hung, et al.
Publicado: (2020)

Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence
por: Lin, I-Hsuan, et al.
Publicado: (2011)

BCRP/ABCG2 Inhibition Sensitizes Hepatocellular Carcinoma Cells to Sorafenib
por: Huang, Wei-Chien, et al.
Publicado: (2013)

Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus
por: Chuang, Huai-Chia, et al.
Publicado: (2022)

CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity
por: Chen, Ruo-Yu, et al.
Publicado: (2019)

The Development of Light-Curable Calcium-Silicate-Containing Composites Used in Odontogenic Regeneration
por: Lin, Yi-Ting, et al.
Publicado: (2021)

The impact of esophagogastric varices on the prognosis of patients with hepatocellular carcinoma
por: Hsieh, Wei-Yao, et al.
Publicado: (2017)

Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease
por: Hung, Chung-Lin, et al.
Publicado: (2015)

Asiatic Acid, Extracted from Centella asiatica and Induces Apoptosis Pathway through the Phosphorylation p38 Mitogen-Activated Protein Kinase in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells
por: Liu, Yen-Tze, et al.
Publicado: (2020)

Short Half-Life of Des-γ-Carboxy Prothrombin Is a Superior Factor for Early Prediction of Outcomes of Hepatocellular Carcinoma Treated with Radiofrequency Ablation
por: Yao, Chih-Chien, et al.
Publicado: (2023)

The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells
por: Chiang, Cheng-Yen, et al.
Publicado: (2020)

Increased Risk of Pyogenic Liver Abscess Among Patients With Colonic Diverticular Diseases: A Nationwide Cohort Study
por: Tsai, Ming-Shian, et al.
Publicado: (2015)

Platyphyllenone Induces Autophagy and Apoptosis by Modulating the AKT and JNK Mitogen-Activated Protein Kinase Pathways in Oral Cancer Cells
por: Liu, Yen-Tze, et al.
Publicado: (2021)

Well-Controlled Viremia Predicts the Outcome of Hepatocellular Carcinoma in Chronic Viral Hepatitis Patients Treated with Sorafenib
por: Kuo, Yuan-Hung, et al.
Publicado: (2022)

MicroRNA Gene Polymorphisms and Environmental Factors Increase Patient Susceptibility to Hepatocellular Carcinoma
por: Chu, Yin-Hung, et al.
Publicado: (2014)

Hepatic Clostridium Perfringens Abscess Formation after Radiofrequency Ablation Therapy for Hepatocellular Carcinoma: Report of a Rare Case
por: Wang, Ming-Hung, et al.
Publicado: (2021)

Pinostilbene Hydrate Inhibits the Migration and Invasion of Human Nasopharyngeal Carcinoma Cells by Downregulating MMP-2 Expression and Suppressing Epithelial–Mesenchymal Transition Through the Mitogen-Activated Protein Kinase Signaling Pathways
por: Tseng, Pao-Yu, et al.
Publicado: (2019)

Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1
por: Woo, Stephanie, et al.
Publicado: (2012)

Predicting outcomes for recurrent hepatocellular carcinoma within Milan criteria after complete radiofrequency ablation
por: Chen, Hsin-Yeh, et al.
Publicado: (2020)

A comparison of prognoses between surgical resection and radiofrequency ablation therapy for patients with hepatocellular carcinoma and esophagogastric varices
por: Wei, Cheng-Yi, et al.
Publicado: (2020)

Safety and effectiveness of new embolization microspheres SCBRM for intermediate-stage hepatocellular carcinoma: A feasibility study
por: Liu, Yi-Sheng, et al.
Publicado: (2021)

Active hepatocellular carcinoma is an independent risk factor of direct-acting antiviral treatment failure: A retrospective study with prospectively collected data
por: Yen, Yi-Hao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l4l28vicmspt13lvkhn07td2a1