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Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner
Oncogene-induced replication stress (RS) promotes cancer development but also impedes tumor growth by activating anti-cancer barriers. To determine how cancer cells adapt to RS, we have monitored the expression of different components of the ATR-CHK1 pathway in primary tumor samples. We show that un...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385232/ https://www.ncbi.nlm.nih.gov/pubmed/30796221 http://dx.doi.org/10.1038/s41467-019-08886-8 |