Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Oncogene-induced replication stress (RS) promotes cancer development but also impedes tumor growth by activating anti-cancer barriers. To determine how cancer cells adapt to RS, we have monitored the expression of different components of the ATR-CHK1 pathway in primary tumor samples. We show that un...

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Detalles Bibliográficos
Autores principales: Bianco, Julien N., Bergoglio, Valérie, Lin, Yea-Lih, Pillaire, Marie-Jeanne, Schmitz, Anne-Lyne, Gilhodes, Julia, Lusque, Amelie, Mazières, Julien, Lacroix-Triki, Magali, Roumeliotis, Theodoros I., Choudhary, Jyoti, Moreaux, Jérôme, Hoffmann, Jean-Sébastien, Tourrière, Hélène, Pasero, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385232/
https://www.ncbi.nlm.nih.gov/pubmed/30796221
http://dx.doi.org/10.1038/s41467-019-08886-8

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