Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis

Gambogic acid (GA), a xanthonoid extracted from the resin of the tree, Garcinia hanburyi, was recently shown to exert anticancer activity in multiple studies, but the underlying action mechanism remains unclear. Here, we show that GA induces cancer cell death accompanied by vacuolation in vitro and...

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Detalles Bibliográficos
Autores principales: Seo, Min Ji, Lee, Dong Min, Kim, In Young, Lee, Dongjoo, Choi, Min-Koo, Lee, Joo-Youn, Park, Seok Soon, Jeong, Seong-Yun, Choi, Eun Kyung, Choi, Kyeong Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385239/
https://www.ncbi.nlm.nih.gov/pubmed/30796201
http://dx.doi.org/10.1038/s41419-019-1360-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385239/
https://www.ncbi.nlm.nih.gov/pubmed/30796201
http://dx.doi.org/10.1038/s41419-019-1360-4

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